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The Histology Core provides high-quality, cost-effective and time-efficient histological and imaging analysis of human and animal tissues of digestive inflammatory and metabolic diseases, such as inflammatory bowel disease, hepatitis, metabolic syndromes and obesity. As part of the Cleveland Digestive Diseases Research Core Center (DDRCC), the core can provide basic, high-quality histologic and immunohistochemistry (IHC) services in a cost-effective and timely fashion. We can also provide initial service, consultation and subsequent training for special IHC staining in gastrointestinal (GI) and liver tissues and provide consistent and validated histological scoring of GI and liver inflammation, fibrosis and dysplasia for preclinical and clinical studies. Furthermore, we can provide publication-ready photo documentation of acquired histological, IHC and IF stained images and provide access to an animal tissue repository of histological blocks and slides of various models of Gl and liver inflammatory and metabolic disease.